Bioactive Constituents from Fresh Fruits of Randia Siamensis

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چکیده

Bioactive-directed fractionation of n-butanol extract from fresh fruits of Randia siamensis led to isolate of 4 new pseudoginsenoside compounds: pseudoginsenosides-RT2, -RT3, RT4 and -RT5, together with 7 known compounds: tyramine, pseudoginsenosides-RT1 methyl ester, pseudoginsenosides-RT1, pseudoginsenoside-RP1, kaempferol-3-O-β-D-xylose(1-2)-βgalactose, kaempferol-3-O-β-D-galactose, and 5-O-[Z] caffeoylquinic acid. Structures of the compounds were analyzed by NMR, MS and GC. Tyramine is responsible for the hypertensive activity, whereas pseudoginsenosides-RT1 and pseudoginsenoside-RP1 are responsible for the hypotensive activity.

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Biol. Pharm. Bull. 30(1) 96—104 (2007)

subfamily Gardennieae, family Rubiaceae. It is widely distributed in tropical and sub-tropical regions, especially in Asia and Africa. Craib reported that R. siamensis CRAIB is synonymous with R. longiflora HOOK f., R. uncata RIDL., Griffithia siamensis MIQ. and Webera siamensis KURZ. It can be found in all parts of Thailand and Burma, especially in humid regions. This plant is known by various...

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تاریخ انتشار 2007